Description

3-Chloro-2-Fluoro-4-Methylpyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine and chlorine atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Useful for creating labeled compounds or molecular probes for biochemical and diagnostic research applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine scaffolds.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-Methylpyridine
CAS No.	1214377-89-5
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	2-Fluoro-3-chloro-4-methylpyridine; 4-Methyl-3-chloro-2-fluoropyridine; 3-Chloro-2-fluoro-4-picoline; Pyridine, 3-chloro-2-fluoro-4-methyl-; 1214377-89-5; 3-Chloro-2-fluoro-4-methyl-pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-4-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.