Description

5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both bromine and trifluoromethyl substituents on a pyridine-carbonitrile core, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex substituents.
• Functional Group Transformation: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or converted into heterocycles like tetrazoles, expanding its utility.

Basic Information

Item	Details
Product Name	5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile
CAS No.	1214377-57-7
Molecular Formula	C7H2BrF3N2
Molecular Weight	250.99 g/mol
Synonyms	5-Bromo-3-(trifluoromethyl)picolinonitrile; 2-Cyano-5-bromo-3-(trifluoromethyl)pyridine; 5-Bromo-3-trifluoromethylpyridine-2-carbonitrile; 5-Bromo-3-(trifluoromethyl)-2-cyanopyridine; 2-Pyridinecarbonitrile, 5-bromo-3-(trifluoromethyl)-; 1214377-57-7
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.