Description

3-(Difluoromethoxy)-2-Fluoro-Pyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique difluoromethoxy and fluoro substituents make it an essential intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, contributing to materials with unique electronic and surface properties.
• Chemical Biology Probes: Utilized as a building block for fluorinated probes and tags used in bioimaging and diagnostic assay development.

Basic Information

Product Name	3-(Difluoromethoxy)-2-Fluoro-Pyridine
CAS No.	1214377-44-2
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	2-Fluoro-3-(difluoromethoxy)pyridine; 3-(Difluoromethoxy)-2-fluoropyridine; Pyridine, 2-fluoro-3-(difluoromethoxy)-; 1214377-44-2; 2-Fluoro-3-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethoxy)-2-Fluoro-Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry and inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.