Description

4-Methyl-3-(trifluoromethyl)pyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a pyridine core with a trifluoromethyl group, offers exceptional properties for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Item	Detail
Product Name	4-Methyl-3-(trifluoromethyl)pyridine
CAS No.	1214344-10-1
Molecular Formula	C7H6F3N
Molecular Weight	161.12 g/mol
Synonyms	3-(Trifluoromethyl)-4-picoline; 4-Methyl-3-(trifluoromethyl)pyridine; 3-Trifluoromethyl-4-methylpyridine; 4-Methyl-3-trifluoromethylpyridine; Pyridine, 4-methyl-3-(trifluoromethyl)-; 4-Methyl-3-(trifluoromethyl)pyridine (CAS 1214344-10-1)
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its properties as a fluoride/strong alkali derivative and high volatility, ensure containers are kept tightly sealed and away from incompatible materials. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.