Description

2-Fluoro-3-Nitrobenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 2-fluoro-3-nitrobenzoyl moiety, a key structural motif for modulating biological activity and material properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and nitro groups enhance bioactivity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce specific functional groups into polymer chains, altering thermal stability, solubility, or reactivity for high-performance materials.
• Peptide & Protein Research: Acts as an acylating agent for modifying amino acids or protecting groups in peptide synthesis.
• Dye & Pigment Manufacturing: Intermediate in the production of complex, high-value dyes and pigments requiring specific light-fastness and color properties.
• Cross-coupling Reactions: Useful substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	2-Fluoro-3-Nitrobenzoyl Chloride
CAS No.	1214341-16-8
Molecular Formula	C7H3ClFNO3
Molecular Weight	203.56 g/mol
Synonyms	2-Fluoro-3-nitrobenzoic acid chloride; 3-Nitro-2-fluorobenzoic acid chloride; 2-Fluoro-3-nitrobenzoyl chloride; Benzoic acid, 2-fluoro-3-nitro-, chloride; 2-Fluoro-3-nitrobenzoylchloride; 2-Fluoro-3-nitro-benzoyl chloride; 1214341-16-8 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency meet the highest standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with global regulatory frameworks, including REACH and cGMP where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents. Keep away from heat, sparks, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain purity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.