Description

Ethyl 2-Bromo-5-Chloronicotinate is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. This compound is valued for its reactive halogen substituents, which enable precise molecular construction in complex chemical environments. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing nicotinic acid or pyridine scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to synthesize labeled compounds or molecular probes for biochemical and pharmacological studies.

Basic Information

Product Name	Ethyl 2-Bromo-5-Chloronicotinate
CAS No.	1214337-49-1
Molecular Formula	C8H7BrClNO2
Molecular Weight	264.50 g/mol
Synonyms	2-Bromo-5-chloronicotinic acid ethyl ester; Ethyl 2-bromo-5-chloropyridine-3-carboxylate; 5-Chloro-2-bromonicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 2-bromo-5-chloro-, ethyl ester; 2-Bromo-5-chloro-3-pyridinecarboxylic acid ethyl ester; Ethyl 5-chloro-2-bromonicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-5-Chloronicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our commitment to quality supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.