Description

Methyl 3-Bromo-5-Fluoropyridine-2-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its precise molecular architecture, enabling the efficient construction of complex pharmacophores and agrochemical intermediates. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, CNS agents, and anti-infective drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands, metal-organic frameworks (MOFs), and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Building Block: The presence of fluorine is exploited in medicinal chemistry to modulate pharmacokinetic properties like metabolic stability and membrane permeability.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs) developing proprietary compounds.

Basic Information

Product Name	Methyl 3-Bromo-5-Fluoropyridine-2-Carboxylate
CAS No.	1214337-00-4
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	3-Bromo-5-fluoro-2-pyridinecarboxylic acid methyl ester; Methyl 3-bromo-5-fluoropicolinate; 2-Pyridinecarboxylic acid, 3-bromo-5-fluoro-, methyl ester; 3-Bromo-5-fluoropyridine-2-carboxylic acid methyl ester; Methyl 3-bromo-5-fluoropyridine-2-carboxylate; 1214337-00-4
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Bromo-5-Fluoropyridine-2-Carboxylate is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC/GC purity profiles and impurity characterization. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis. Specifications and stability data are available to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.