Description

2-Bromo-3-Nitro-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block of significant importance in modern synthetic chemistry. Its unique structure, featuring bromo, nitro, and trifluoromethyl substituents on a pyridine core, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its derivatization potential is key to innovation.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a key monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: The nitro group activates the pyridine ring for substitution reactions, allowing for further functionalization.
• Fluorine Chemistry Building Block: The stable -CF3 group introduces desirable properties like increased lipophilicity and metabolic resistance into target molecules.

Basic Information

Product Name	2-Bromo-3-Nitro-5-(Trifluoromethyl)Pyridine
CAS No.	1214336-90-9
Molecular Formula	C6H2BrF3N2O2
Molecular Weight	270.99 g/mol
Synonyms	5-(Trifluoromethyl)-3-nitro-2-bromopyridine; 2-Bromo-3-nitro-5-trifluoromethylpyridine; 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine; Pyridine, 2-bromo-3-nitro-5-(trifluoromethyl)-; 1214336-90-9
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Nitro-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.