Description

[2-Bromo-3-(Trifluoromethyl)Phenyl]Methanol is a high-value fluorinated aromatic building block featuring both bromine and trifluoromethyl substituents, offering versatile reactivity for advanced molecular synthesis. This compound is essential for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. Its primary utility lies in serving as a key intermediate in cross-coupling reactions and further functionalization to create complex, performance-enhancing molecules.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances product efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and polymers with unique electronic and surface properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to construct biaryl and complex aromatic systems.
• Further Functionalization: The benzylic alcohol group can be oxidized to aldehydes, esterified, or used to introduce other functional handles for library synthesis.

Basic Information

Product Name	[2-Bromo-3-(Trifluoromethyl)Phenyl]Methanol
CAS No.	1214330-94-5
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	(2-Bromo-3-(trifluoromethyl)phenyl)methanol; 1-Bromo-2-(hydroxymethyl)-6-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-m-toluyl alcohol; [2-Bromo-3-(trifluoromethyl)benzenemethanol]; Benzenemethanol, 2-bromo-α,α,α-trifluoro-; α,α,α-Trifluoro-2-bromo-m-toluyl alcohol
EINECS	Contact for details

Quality Control

Every batch of [2-Bromo-3-(Trifluoromethyl)Phenyl]Methanol is produced and analyzed under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency, supported by comprehensive analytical documentation. Our standard quality commitment includes identity confirmation via spectroscopic methods and quantitative purity assessment. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.