Description

4-Amino-3-Bromo-5-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures with precise electronic and steric properties. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients, particularly in the areas of agrochemicals and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for biochemical and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring specific halogenated aminopyridine motifs.

Basic Information

Product Name	4-Amino-3-Bromo-5-Fluoropyridine
CAS No.	1214326-89-2
Molecular Formula	C5H4BrFN2
Molecular Weight	191.00 g/mol
Synonyms	3-Bromo-5-fluoro-4-pyridinamine; 5-Fluoro-3-bromo-4-aminopyridine; 4-Pyridinamine, 3-bromo-5-fluoro-; 3-Bromo-5-fluoropyridin-4-amine; 4-Amino-3-bromo-5-fluoropyridine; 1214326-89-2; 3-Br-5-F-4-NH2-Py
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-5-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.