Description

2-Bromo-5-Chloro-Nicotinic Acid Methyl Ester is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. This compound is valued for its halogenated pyridine structure, which provides versatile reactivity for constructing complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated nicotinic acid scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Bromo-5-Chloro-Nicotinic Acid Methyl Ester
CAS No.	1214324-95-4
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	Methyl 2-Bromo-5-chloronicotinate; 2-Bromo-5-chloropyridine-3-carboxylic acid methyl ester; 5-Chloro-2-bromonicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 2-bromo-5-chloro-, methyl ester; Methyl 5-chloro-2-bromonicotinate; 2-Bromo-5-chloro-3-pyridinecarboxylic acid methyl ester; 1214324-95-4
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Chloro-Nicotinic Acid Methyl Ester is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the rigorous demands of process chemistry and regulatory filings. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.