Description

N3-Peg8-Ch2Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide (N3) group and a carboxylic acid (COOH) terminus, separated by a flexible 8-unit PEG spacer. This compound is essential for creating stable, biocompatible conjugates in bioconjugation and click chemistry applications, enabling the precise attachment of biomolecules, drugs, or probes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing advanced therapeutics and research tools.

Application

• Bioconjugation reagent for linking azide-modified biomolecules (e.g., antibodies, peptides) to carboxyl-reactive surfaces or molecules.
• Key intermediate in the synthesis of antibody-drug conjugates (ADCs) and peptide-drug conjugates via copper-free click chemistry.
• Surface functionalization of nanoparticles, quantum dots, and other nanomaterials for targeted drug delivery and imaging.
• Modification of polymers and hydrogels to introduce bio-orthogonal reactive sites for further chemical grafting.
• Proteomics research for labeling and pull-down assays using azide-alkyne cycloaddition.
• Development of diagnostic kits and biosensors that require stable, hydrophilic spacer arms.

Basic Information

Product Name	N3-Peg8-Ch2Ch2Cooh
CAS No.	1214319-92-2
Molecular Formula	C25H47N3O12
Molecular Weight	581.66 g/mol
Synonyms	Azido-PEG8-acid; N3-PEG8-COOH; 8-Azido-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid; Azido-PEG8-acetic acid; PEG8-azide-acid; Azido-OEG8-acid; 2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Heterobifunctional PEG linker, N3-PEG8-acid
EINECS	Contact for details

Quality Control

Our N3-Peg8-Ch2Ch2Cooh is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. Each lot is characterized by NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant to maintain stability, as the material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.