Description

4-Bromo-2-(Difluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethyl substituents, makes it an indispensable intermediate for introducing specific pharmacophores and modifying physicochemical properties in target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Employed in the synthesis of specialized ligands for catalysis, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics and structural rigidity.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) for constructing complex biaryl and heterobiaryl systems.
• Fluorine Chemistry Building Block: The difluoromethyl moiety acts as a valuable isostere for other functional groups, enabling fine-tuning of lipophilicity and metabolic properties in drug design.

Basic Information

Product Name	4-Bromo-2-(Difluoromethyl)Pyridine
CAS No.	1214094-90-2
Molecular Formula	C6H4BrF2N
Molecular Weight	207.99 g/mol
Synonyms	2-(Difluoromethyl)-4-bromopyridine; 4-Bromo-2-difluoromethylpyridine; Pyridine, 4-bromo-2-(difluoromethyl)-; 1214094-90-2
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.