Description

(2R)-2-Amino-2-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Ol CAS NO 1212817-81-6 is a high-purity chiral amino alcohol building block featuring a trifluoromethyl and fluorine-substituted aromatic ring. This compound is critical for pharmaceutical research and development, particularly in the synthesis of active pharmaceutical ingredients (APIs) where its specific stereochemistry and fluorine motifs can enhance metabolic stability and binding affinity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, especially in central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in developing advanced pesticides and herbicides where the fluorine and trifluoromethyl groups contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the synthesis of specialty polymers and liquid crystals with unique electronic properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and protein interactions.
• Process Chemistry & Scale-up: A critical building block for optimizing synthetic routes from laboratory to pilot and commercial scale.

Basic Information

Product Name	(2R)-2-Amino-2-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Ol
CAS No.	1212817-81-6
Molecular Formula	C9H7F4NO
Molecular Weight	221.15 g/mol
Synonyms	(2R)-2-Amino-2-(2-Fluoro-4-(trifluoromethyl)phenyl)ethanol; (R)-2-Amino-2-(2-fluoro-4-(trifluoromethyl)phenyl)ethan-1-ol; 2-Fluoro-α-(aminomethyl)-4-(trifluoromethyl)benzenemethanol (R)-; (R)-1-(2-Fluoro-4-(trifluoromethyl)phenyl)-2-aminoethanol; 1212817-81-6; Benzenemethanol, 2-fluoro-α-(aminomethyl)-4-(trifluoromethyl)-, (αR)-; (2R)-2-Azanyl-2-[2-fluoro-4-(trifluoromethyl)phenyl]ethan-1-ol
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-2-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.