Description

(2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-3-Methylbutanoic Acid is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which make it a critical precursor in the synthesis of complex active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of proprietary drug candidates, particularly in oncology and central nervous system (CNS) research.
• API Development: Used as a building block for constructing complex molecular architectures in the research and development of new active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (2S)-configured chiral center into target molecules, ensuring high enantiomeric purity.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale manufacturing for clinical trial material and commercial API production.
• Bioconjugation & Prodrug Synthesis: Its carboxylic acid functionality allows for conjugation chemistry, useful in creating prodrugs or targeted drug delivery systems.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Item	Details
Product Name	(2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-3-Methylbutanoic Acid
CAS No.	1212421-96-9
Molecular Formula	C13H12N2O5
Molecular Weight	276.25 g/mol
Synonyms	(S)-2-(1,3-Dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-3-methylbutanoic acid; (2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanoic acid (related fused ring system); 2H-Pyrrolo[3,4-c]pyridine-2-propanoic acid, 1,3-dihydro-1,3-dioxo-α-(1-methylethyl)-, (αS)-; Chiral Isoindole-1,3-dione Derivative; Valine-derived Isoindoledione; Pharmaceutical Intermediate 1212421-96-9
EINECS	Contact for details

Quality Control

Our (2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-3-Methylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.