Description

(2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-4-Methylpentanoic Acid is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Protease Inhibitor Research: Serves as a core structural component in the development of novel protease inhibitors due to its pyrrolopyridine scaffold.
• Asymmetric Synthesis: Utilized as a building block in stereoselective chemical reactions to introduce chiral centers into target molecules.
• Peptidomimetic Development: Incorporated into the design of peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Chemical Biology Probes: Used in the creation of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Item	Details
Product Name	(2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-4-Methylpentanoic Acid
CAS No.	1212195-99-7
Molecular Formula	C14H14N2O4
Molecular Weight	274.27 g/mol
Synonyms	(2S)-2-(1,3-Dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-4-methylpentanoic acid; (S)-2-(1,3-Dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-4-methylpentanoic acid; 2H-Pyrrolo[3,4-c]pyridine-2-propanoic acid, 1,3-dihydro-1,3-dioxo-α-(2-methylpropyl)-, (αS)-; (S)-2-(1,3-Dioxoisoindolin-2-yl)-4-methylpentanoic acid (related isoindoline analog); Chiral Pyrrolopyridine Derivative; CAS 1212195-99-7; Pharmaceutical Intermediate 1212195-99-7
EINECS	Contact for details

Quality Control

Our (2S)-2-(1,3-Dioxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]-Pyridin-2-Yl)-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.