Description

4-Bromo-2,3-Dihydro-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate (API) featuring a fused pyrrolopyridine scaffold with a bromine substituent, enabling precise synthetic modifications. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting protein kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable bromine handle.
• Biochemical Probe Development: Serves as a core scaffold for creating tool compounds to study biological pathways and enzyme functions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP conditions.
• Library Synthesis: A valuable input for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	4-Bromo-2,3-Dihydro-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1211582-69-2
Molecular Formula	C12H15BrN2O2
Molecular Weight	299.17 g/mol
Synonyms	1-Boc-4-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; tert-Butyl 4-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 4-Bromo-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; 4-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester; 4-Bromo-1-Boc-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-Dihydro-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.