Description

Methyl 4-Chloro-6-(Trifluoromethyl)Nicotinate is a high-value fluorinated nicotinate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of a halogenated pyridine core and a trifluoromethyl group, which are pivotal for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in developing kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized ligands and organic frameworks in specialty chemical applications.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring fluorinated heterocyclic architectures.

Basic Information

Product Name	Methyl 4-Chloro-6-(Trifluoromethyl)Nicotinate
CAS No.	1211539-36-4
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 4-chloro-6-(trifluoromethyl)pyridine-3-carboxylate; 4-Chloro-6-(trifluoromethyl)nicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 4-chloro-6-(trifluoromethyl)-, methyl ester; Methyl 4-chloro-6-trifluoromethylnicotinate; 4-Chloro-6-trifluoromethyl-nicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Chloro-6-(Trifluoromethyl)Nicotinate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.