Description

5-Bromo-4-Methylpyridine-2-Carbonyl Chloride is a versatile and highly reactive organic building block, specifically an acid chloride derivative of a substituted pyridine. Its primary value lies in its role as a key synthetic intermediate, enabling the efficient introduction of the 5-bromo-4-methylpicolinoyl moiety into more complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for constructing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogen and reactive carbonyl groups for structural diversification.
• Ligand and Catalyst Development: Serves as a building block for creating complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its aromatic pyridine core.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and R&D: A valuable starting material for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	5-Bromo-4-Methylpyridine-2-Carbonyl Chloride
CAS No.	1211537-23-3
Molecular Formula	C7H5BrClNO
Molecular Weight	234.48 g/mol
Synonyms	5-Bromo-4-methylpicolinoyl chloride; 2-Pyridinecarbonyl chloride, 5-bromo-4-methyl-; 5-Bromo-4-methyl-2-pyridinecarbonyl chloride; 5-Bromo-4-methylpyridine-2-carboxylic acid chloride; 4-Methyl-5-bromopicolinoyl chloride; 5-Bromo-4-methylpicolinic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Methylpyridine-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Recommended long-term storage temperature is 2-8°C. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.