Description

4-Bromo-3-Chloro-2-Fluoropyridine is a high-purity halogenated pyridine derivative, a crucial building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecules with high precision and selectivity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and heterobiaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 2-position is highly activated for substitution, enabling further functionalization.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	4-Bromo-3-Chloro-2-Fluoropyridine
CAS No.	1211528-25-4
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	2-Fluoro-4-bromo-3-chloropyridine; 3-Chloro-4-bromo-2-fluoropyridine; 4-Bromo-3-chloro-2-fluoro-pyridine; Pyridine, 4-bromo-3-chloro-2-fluoro-; 2-Fluoro-3-chloro-4-bromopyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.