Description

2-Bromo-5-(1,1-Difluoroethyl)Pyridine is a high-purity, halogenated pyridine derivative serving as a critical advanced pharmaceutical intermediate and organic building block. Its unique structure, featuring both bromine and difluoroethyl substituents, makes it an essential reagent for introducing specific functionalities into complex molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging its halogenated pyridine core.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystal materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Ligand Synthesis: Utilized for constructing novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Life Science Research: Employed as a biochemical tool and probe in medicinal chemistry research for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Bromo-5-(1,1-Difluoroethyl)Pyridine
CAS No.	1211521-60-6
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	5-(1,1-Difluoroethyl)-2-bromopyridine; 2-Bromo-5-(1,1-difluoroethyl)pyridine; 2-Bromo-5-(α,α-difluoroethyl)pyridine; Pyridine, 2-bromo-5-(1,1-difluoroethyl)-; 1211521-60-6; 2-Bromo-5-(difluoroethyl)pyridine; 2-Bromopyridine-5-(1,1-difluoroethane)
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(1,1-Difluoroethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.