Description

Ribociclib CAS NO 1211441-98-3 is a highly selective and potent small molecule inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). This compound matters as a critical active pharmaceutical ingredient (API) in targeted cancer therapies, offering a mechanism to disrupt uncontrolled cell proliferation. It is primarily needed by pharmaceutical manufacturers and research institutions developing and producing treatments for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of anti-cancer drugs.
• Key intermediate in advanced pharmaceutical synthesis and process development.
• Reference standard for quality control and analytical testing in pharmaceutical laboratories.
• Biochemical research tool for studying CDK4/6 inhibition and cell cycle regulation.
• Pre-clinical and clinical research material for oncology drug discovery programs.

Basic Information

Product Name	Ribociclib
CAS No.	1211441-98-3
Molecular Formula	C23H30N8O
Molecular Weight	434.54 g/mol
Synonyms	LEE011; Kisqali; Ribociclib Succinate; 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; LEE-011; 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
EINECS	Contact for details

Quality Control

Our Ribociclib is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing parameters such as assay, purity, and identification. We adhere to cGMP guidelines where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.