Description

6-Chloro-2,3-Difluorobenzoyl Chloride, 97% is a high-purity, multi-functional aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites—the highly electrophilic acid chloride group and the halogenated aromatic ring—which enable precise and efficient construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorobenzoyl motifs.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides that require halogenated aromatic structures for enhanced bioactivity and stability.
• Liquid Crystal & OLED Material Production: Used in creating advanced organic electronic materials and liquid crystal compounds where fluorine substitution is crucial for performance.
• Polymer Chemistry: Monomer or modifier for synthesizing specialty polymers, including high-performance polyamides and polyesters.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Peptide Mimetic & Drug Discovery: Useful for introducing the benzoyl group into peptide backbones or small molecule candidates during medicinal chemistry research.

Basic Information

Product Name	6-Chloro-2,3-Difluorobenzoyl Chloride, 97%
CAS No.	1208078-25-4
Molecular Formula	C7H2Cl2F2O
Molecular Weight	211.00 g/mol
Synonyms	2,3-Difluoro-6-chlorobenzoyl chloride; 6-Chloro-2,3-difluorobenzoic acid chloride; Benzoyl chloride, 6-chloro-2,3-difluoro-; 2,3-Difluoro-6-chlorobenzoic acid chloride; 6-Chloro-2,3-difluorobenzoic chloride; (6-Chloro-2,3-difluorophenyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,3-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure the specified purity of 97% (minimum) and to control critical impurities. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for optimal long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.