Description

1,3-Difluoro-4-Iodo-2-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of fluorine and iodine substituents on the methylbenzene scaffold makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and iodinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the difluoro and iodo groups can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials with tailored optical and electronic properties.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Stille couplings, enabling rapid diversification of chemical space.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of adjacent fluorine atoms on the reactivity of aryl iodides in nucleophilic aromatic substitution and other transformations.

Basic Information

Product Name	1,3-Difluoro-4-Iodo-2-Methylbenzene
CAS No.	1208077-89-7
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	4-Iodo-1,3-difluoro-2-methylbenzene; 2-Methyl-1,3-difluoro-4-iodobenzene; 1,3-Difluoro-4-iodo-2-methyl-benzene; 2,4-Difluoro-6-iodo-3-methylbenzene; 3-Methyl-2,4-difluoro-1-iodobenzene; Benzene, 1,3-difluoro-4-iodo-2-methyl-; 1208077-89-7
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-4-Iodo-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.