Description

2-Chloro-6-Fluoro-4-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group, makes it an indispensable intermediate for creating compounds with tailored electronic and steric properties. This product is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups improve biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for functional materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive chlorine substituent.
• Fluorinated Compound Library: Integral for medicinal chemistry programs focused on expanding fluorinated compound libraries to explore structure-activity relationships (SAR).
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in organic synthesis and methodology development.

Basic Information

Item	Detail
Product Name	2-Chloro-6-Fluoro-4-(Trifluoromethyl)Pyridine
CAS No.	1207665-87-9
Molecular Formula	C6H2ClF4N
Molecular Weight	199.53 g/mol
Synonyms	2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-chloro-6-fluoropyridine; 2-Chloro-6-fluoro-α,α,α-trifluoro-picoline; 2-Chloro-6-fluoro-4-trifluoromethylpyridine; Pyridine, 2-chloro-6-fluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluoro-4-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We guarantee high purity and consistency to meet the exacting standards of advanced synthetic applications. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.