Description

1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile, 5-Bromo- is a high-value brominated heterocyclic building block, specifically a substituted pyrrolopyridine-carbonitrile derivative. This compound is critical for medicinal chemistry research and development, serving as a versatile intermediate for constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its reactive bromine and nitrile functional groups.
• Agrochemical Synthesis: Serves as a building block for developing new crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Material Science Research: Potential intermediate for the development of organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile, 5-Bromo-
CAS No.	1207625-52-2
Molecular Formula	C8H4BrN3
Molecular Weight	222.04 g/mol
Synonyms	5-Bromo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 5-Bromo-4-cyano-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 5-Bromo-7-azaindole-4-carbonitrile; 4-Cyano-5-bromo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-cyanopyrrolo[2,3-b]pyridine; 5-Bromo-1H-7-azaindole-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile, 5-Bromo- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.