Description

Bmn 673 CAS NO 1207456-01-6 is a potent and selective small molecule inhibitor of poly (ADP-ribose) polymerase (PARP), a key enzyme involved in DNA repair. This compound is of significant value in oncology research, particularly for studying synthetic lethality in cancers with homologous recombination deficiencies, such as those involving BRCA mutations. It is an essential research-grade chemical for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel cancer therapeutics and understanding DNA damage response pathways.

Application

• Oncology Research & Drug Discovery: A critical tool for investigating the mechanism of PARP inhibition and its role in inducing synthetic lethality in cancer cells.
• Biochemical Assay Development: Used as a reference standard and active agent in high-throughput screening (HTS) and in vitro enzymatic assays targeting PARP enzymes.
• Preclinical Studies: Employed in cell-based models and animal studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of PARP inhibitor-based treatment strategies.
• Combination Therapy Research: Studied in conjunction with other chemotherapeutic agents or radiation therapy to explore synergistic anti-tumor effects.
• Mechanistic Biology: Fundamental research into DNA repair pathways, genomic instability, and cellular response to genotoxic stress.

Basic Information

Product Name	Bmn 673
CAS No.	1207456-01-6
Molecular Formula	C19H14F2N6O
Molecular Weight	380.35 g/mol
Synonyms	Talazoparib; BMN-673; BMN 673; (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one; LT-673; MDV3800
EINECS	Contact for details

Quality Control

Our Bmn 673 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.