Description

2-Bromo-3-(trifluoromethoxy)pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring both bromine and a trifluoromethoxy substituent, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysis.
• Material Science Research: Employed in the creation of organic electronic materials, such as components for OLEDs or conductive polymers, due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-3-(trifluoromethoxy)pyridine
CAS No.	1206978-11-1
Molecular Formula	C6H3BrF3NO
Molecular Weight	241.99 g/mol
Synonyms	2-Bromo-3-(trifluoromethoxy)pyridine; 3-Trifluoromethoxy-2-bromopyridine; Pyridine, 2-bromo-3-(trifluoromethoxy)-; 2-Bromo-3-trifluoromethoxypyridine; 2-Bromo-3-(trifluoromethoxy)pyridine (CAS 1206978-11-1); 2-Br-3-OCF3-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-(trifluoromethoxy)pyridine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.