Description

Ly2801653 is a potent and selective small molecule inhibitor of the c-Met (mesenchymal-epithelial transition factor) receptor tyrosine kinase. This compound is of significant interest in pharmaceutical research and development due to its role in targeting signaling pathways associated with tumor growth, metastasis, and angiogenesis. It is primarily utilized by researchers and pharmaceutical companies in the fields of oncology and medicinal chemistry for preclinical studies, assay development, and as a reference standard.

Application

• Oncology Research: Used as a key biochemical tool to study the role of c-Met signaling in various cancer models, including lung, gastric, and liver cancers.
• Drug Discovery & Development: Serves as a reference compound or positive control in high-throughput screening (HTS) assays to identify and validate novel c-Met inhibitors.
• Mechanistic Studies: Employed to investigate downstream pathways (e.g., PI3K/Akt, MAPK/ERK) and cellular processes like proliferation, migration, and invasion.
• Preclinical In Vitro/In Vivo Studies: Utilized in cell-based assays and animal models to evaluate antitumor efficacy and pharmacokinetic properties.
• Biomarker Research: Aids in exploring potential biomarkers for patient stratification and predicting response to c-Met-targeted therapies.
• Chemical Biology: Acts as a starting point or intermediate for the synthesis of more potent or selective analogs in medicinal chemistry programs.

Basic Information

Product Name	Ly2801653
CAS No.	1206799-15-6
Molecular Formula	C₂₈H₂₈N₆O₃
Molecular Weight	496.56 g/mol
Synonyms	LY2801653; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-(4-fluoro-2-methylphenyl)-N-(4-fluorophenyl)-1-phenyl-; c-Met inhibitor LY2801653; 6-(4-Fluoro-2-methylphenyl)-N-(4-fluorophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; UNII-8J8Q3K2V0F; 8J8Q3K2V0F; Merestinib analog
EINECS	Contact for details

Quality Control

Our Ly2801653 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.