Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 4-Chloro-1-[(4-Methylphenyl)Sulfonyl] is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and other therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

This specialized intermediate serves as a key precursor in several high-value chemical synthesis pathways.

• Pharmaceutical Intermediate: Core building block for the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for API manufacturing.
• Biochemical Research: Potential use as a probe or tool compound in biochemical assays due to its specific molecular scaffold.
• Custom Synthesis: Basis for the custom manufacturing of complex, proprietary molecules for client-specific projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 4-Chloro-1-[(4-Methylphenyl)Sulfonyl]
CAS No.	1204809-92-6
Molecular Formula	C15H11ClN2O4S
Molecular Weight	350.78 g/mol
Synonyms	4-Chloro-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 4-Chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 4-Chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-chloro-1-[(4-methylphenyl)sulfonyl]-; 1204809-92-6; 4-Chloro-1-tosyldeazapurine-2-carboxylic acid (analogous naming).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure structural identity and purity. A Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each shipment. We support development and cGMP-grade requirements, with specifications tailored to your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.