Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Ethynyl- is a high-value heterocyclic building block featuring a fused pyrrolopyridine core with both carboxylic acid and ethynyl functional groups. This unique bifunctional structure makes it a critical intermediate for constructing complex molecular architectures in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Chemical Biology Probes: The ethynyl group enables conjugation via click chemistry for labeling and studying biological targets.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development of candidate drugs.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS).
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Item	Detail
Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Ethynyl-
CAS No.	1204475-96-6
Molecular Formula	C10H6N2O2
Molecular Weight	186.17 g/mol
Synonyms	3-Ethynyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Ethynyl-7-azaindole-2-carboxylic acid; 3-Ethynyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Ethynyl-7-aza-1H-indole-2-carboxylic acid; 3-Ethynyl-7-azaindole-2-carboxylic acid; 3-Ethynyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Ethynyl-7-azaindole-2-carboxylic acid; 3-Ethynyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Ethynyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to prevent moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.