Description

tert-Butyl (3R)-3-(Pyridin-2-Ylamino)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected intermediate of significant value in modern synthetic chemistry. This compound matters for its role in constructing complex molecular architectures with precise stereochemical control, which is critical for developing bioactive molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates and approved active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, particularly for kinase inhibitors and receptor modulators.
• Asymmetric Synthesis: Serves as a valuable precursor for introducing the (3R)-3-aminopyrrolidine moiety with high enantiomeric purity into target molecules.
• Peptidomimetics Development: Employed in the design and synthesis of peptidomimetic compounds, where the pyrrolidine scaffold mimics natural amino acid structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions.
• Chemical Reference Standard: Utilized as an analytical standard for quality control and method development in regulatory filings.

Basic Information

Product Name	tert-Butyl (3R)-3-(Pyridin-2-Ylamino)Pyrrolidine-1-Carboxylate
CAS No.	1204421-42-0
Molecular Formula	C14H21N3O2
Molecular Weight	263.34 g/mol
Synonyms	1-Boc-3R-[(2-pyridyl)amino]pyrrolidine; (R)-tert-Butyl 3-((pyridin-2-yl)amino)pyrrolidine-1-carboxylate; (3R)-1-(tert-Butoxycarbonyl)-3-[(2-pyridinyl)amino]pyrrolidine; tert-Butyl (R)-3-(2-pyridylamino)pyrrolidine-1-carboxylate; (R)-3-(Pyridin-2-ylamino)pyrrolidine-1-carboxylic acid tert-butyl ester; 1204421-42-0; Boc-(R)-3-(2-pyridylamino)pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-3-(Pyridin-2-Ylamino)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled and stored away from strong acids and incompatible organic solvents. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.