Description

Icotinib Hydrochloride is a highly selective, small-molecule tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR). This compound is a critical active pharmaceutical ingredient (API) for the development and manufacturing of targeted cancer therapeutics. It is primarily required by pharmaceutical companies and research institutions engaged in oncology drug development, clinical research, and advanced life science studies.

Application

• Oncological API Manufacturing: Serves as the core active ingredient in the formulation of finished dosage forms for targeted cancer therapy.
• Pharmaceutical R&D: Used in preclinical and clinical research for investigating EGFR-mutated non-small cell lung cancer (NSCLC) and other solid tumors.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Mechanistic Studies: A vital tool compound for biochemical and cellular assays to study EGFR signaling pathways and inhibitor mechanisms.
• Drug Discovery: Used as a lead compound or benchmark in medicinal chemistry programs aimed at developing next-generation kinase inhibitors.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and pharmacology research.

Basic Information

Product Name	Icotinib Hydrochloride
CAS No.	1204313-51-8
Molecular Formula	C22H21N3O4 • HCl
Molecular Weight	419.88 g/mol (Free base: 383.42)
Synonyms	BPI-2009H; Conmana (Brand Name); 4-[(3-Ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline Hydrochloride; Icotinib HCl; Icotinib Monohydrochloride; (3-Ethynylphenyl)-[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine Hydrochloride
EINECS	Contact for details

Quality Control

Our Icotinib Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and APIs. A Certificate of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and heavy metals is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.