Description

1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel drug candidates, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds used to study biological pathways and target engagement.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile
CAS No.	1203953-27-8
Molecular Formula	C15H21N3OSi
Molecular Weight	287.44 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; 1-((2-(Trimethylsilyl)ethoxy)methyl)-7-azaindole-5-carbonitrile; 5-Cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; 1-((2-(TMS)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; SEM-Protected 5-Cyano-7-azaindole; 1203953-27-8
EINECS	Contact for details

Quality Control

Our 1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and handled under inert atmosphere (e.g., nitrogen or argon) when necessary to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.