Description

4-Ethyl-n-(4-((3-Ethynylphenyl)Amino)-7-Methoxyquinazolin-6-Yl)Piperazine-1-Carboxamide CAS NO 1203902-67-3 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant interest for its role as a key building block in the research and development of targeted cancer therapies, particularly kinase inhibitors. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and contract research organizations (CROs) engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel small-molecule kinase inhibitors for oncology applications.
• Biochemical Research: Used as a reference standard or active pharmaceutical ingredient (API) starting material in pharmacological and mechanism-of-action studies.
• Drug Discovery & Development: Integral to medicinal chemistry programs aimed at developing targeted therapies for various cancers, including lung, breast, and colorectal.
• Preclinical Studies: Employed in in vitro and in vivo testing to evaluate the efficacy and pharmacokinetic properties of new drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research on cell signaling pathways and apoptosis.

Basic Information

Item	Detail
Product Name	4-Ethyl-n-(4-((3-Ethynylphenyl)Amino)-7-Methoxyquinazolin-6-Yl)Piperazine-1-Carboxamide
CAS No.	1203902-67-3
Molecular Formula	C24H26N6O2
Molecular Weight	430.51 g/mol
Synonyms	4-Ethyl-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide; 1203902-67-3; UNII-9F6H0I8W4F; 9F6H0I8W4F; 4-Ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]-1-piperazinecarboxamide; 1-Piperazinecarboxamide, 4-ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]-; BDBM50164957; AKOS025310647
EINECS	Contact for details

Quality Control

Our 4-Ethyl-n-(4-((3-Ethynylphenyl)Amino)-7-Methoxyquinazolin-6-Yl)Piperazine-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with the standards expected for pharmaceutical R&D, and we can support projects requiring material produced under more stringent controls.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.