Description

4-(Trifluoromethyl)Isoindoline HCl is a high-purity, fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for novel fluorinated polymers and liquid crystals with unique thermal and optical properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	4-(Trifluoromethyl)Isoindoline HCl
CAS No.	1203686-59-2
Molecular Formula	C9H9ClF3N
Molecular Weight	223.62 g/mol
Synonyms	4-(Trifluoromethyl)-2,3-dihydro-1H-isoindole hydrochloride; 1H-Isoindole, 2,3-dihydro-4-(trifluoromethyl)-, hydrochloride; Isoindoline, 4-(trifluoromethyl)-, hydrochloride; 4-(Trifluoromethyl)isoindoline hydrochloride; 4-(Trifluoromethyl)-1H-isoindoline HCl
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Isoindoline HCl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.