Description

6-Bromo-2-Chloro-4-((Trimethylsilyl)Ethynyl)-Pyridin-3-Amine CAS NO 1203499-68-6 is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and chloro leaving groups alongside a protected ethynyl moiety, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted small molecule drugs, particularly kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Building block for creating functional organic materials, including organic semiconductors and liquid crystals.
• Cross-Coupling Reactions: Serves as a versatile substrate in Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions due to its halogen substituents.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Essential reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	6-Bromo-2-Chloro-4-((Trimethylsilyl)Ethynyl)-Pyridin-3-Amine
CAS No.	1203499-68-6
Molecular Formula	C10H12BrClN2Si
Molecular Weight	303.67 g/mol
Synonyms	3-Amino-6-bromo-2-chloro-4-((trimethylsilyl)ethynyl)pyridine; 6-Bromo-2-chloro-4-(2-trimethylsilylethynyl)pyridin-3-amine; 4-((Trimethylsilyl)ethynyl)-6-bromo-2-chloro-pyridin-3-amine; 1203499-68-6; 6-Bromo-2-chloro-4-(trimethylsilylethynyl)-3-pyridinamine
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2-Chloro-4-((Trimethylsilyl)Ethynyl)-Pyridin-3-Amine is manufactured and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.