Description

tert-Butyl 5-((Trimethylsilyl)ethynyl)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate is a sophisticated heterocyclic building block featuring both a protected amine and a silyl-protected alkyne functional group. This compound is of significant value in medicinal chemistry and pharmaceutical research for the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Scaffold: Used for structure-activity relationship (SAR) studies and library synthesis due to its versatile functional handles for further derivatization.
• Agrochemical Research: Employed in the development of new active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probe Synthesis: Acts as a building block for creating molecular probes to study biological pathways and protein functions.
• Material Science: Potential use in the synthesis of organic semiconductors or ligands for catalytic systems, leveraging its conjugated system.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne moiety is a strategic handle for Sonogashira and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	tert-Butyl 5-((Trimethylsilyl)ethynyl)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate
CAS No.	1203499-24-4
Molecular Formula	C17H26N2O3Si
Molecular Weight	334.49 g/mol
Synonyms	1,1-Dimethylethyl 5-[(trimethylsilyl)ethynyl]-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; tert-Butyl 5-(2-trimethylsilylethynyl)-3,4-dihydro-2H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; 5-((Trimethylsilyl)ethynyl)-1,2,3,4-tetrahydro-pyrido[3,4-b][1,4]oxazine-1-carboxylic acid tert-butyl ester; Boc-Protected 5-(TMS-ethynyl)-1,2,3,4-tetrahydro-pyrido[3,4-b][1,4]oxazine; TMS-Ethynyl Pyridoxazine Carboxylate; CAS 1203499-24-4
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-((Trimethylsilyl)ethynyl)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.