Description

Cpi-444 is a potent and selective small molecule inhibitor of the adenosine A2A receptor (A2AR). This compound is of significant interest in pharmaceutical research and development due to its role in modulating immune checkpoint pathways. It is primarily utilized by researchers and developers in the fields of oncology and immunology for investigating novel cancer immunotherapy strategies.

Application

• Immuno-oncology Research: Key tool compound for studying the adenosine-mediated immunosuppressive tumor microenvironment.
• Preclinical Drug Development: Used in *in vitro* and *in vivo* studies to evaluate the efficacy of A2AR blockade in combination with other therapies.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and binding assays to identify and characterize new A2AR antagonists.
• Mechanistic Studies: Facilitates research into the signaling pathways of adenosine receptors and their impact on T-cell and NK cell function.
• Academic Research: Employed in university and institutional labs for fundamental research in immunology and cancer biology.

Basic Information

Product Name	Cpi-444
CAS No.	1202402-40-1
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	PBF-509; Adenosine A2a Receptor Antagonist PBF-509; (S)-5-(5-Amino-3-(4-(2-hydroxypropan-2-yl)phenyl)-1H-pyrazol-1-yl)-N-(2,4-difluorophenyl)pyrazine-2-carboxamide; 2-Pyrazinecarboxamide, 5-[5-amino-3-[4-(1-hydroxy-1-methylethyl)phenyl]-1H-pyrazol-1-yl]-N-(2,4-difluorophenyl)-, (5S)-; Corvus Pharmaceuticals Compound CPI-444
EINECS	Contact for details

Quality Control

Our Cpi-444 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.