Description

3-Chloro-5-(Ethoxycarbonyl)-Pyridine-2-Carboxylic Acid is a high-purity, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a carboxylic acid and an ethoxycarbonyl group on a chlorinated pyridine core, makes it an indispensable precursor for creating complex heterocyclic systems. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridine scaffold is a common bioactive motif.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, metal-organic frameworks (MOFs), and organic electronic materials due to its ability to introduce specific chemical handles.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	3-Chloro-5-(Ethoxycarbonyl)-Pyridine-2-Carboxylic Acid
CAS No.	1200497-77-3
Molecular Formula	C9H8ClNO4
Molecular Weight	229.62 g/mol
Synonyms	2-Carboxy-3-chloro-5-ethoxycarbonylpyridine; 3-Chloro-5-(ethoxycarbonyl)picolinic acid; 5-(Ethoxycarbonyl)-3-chloropyridine-2-carboxylic acid; Ethyl 3-chloro-2-carboxypyridine-5-carboxylate (tautomeric form); 3-Chloro-5-carbethoxypyridine-2-carboxylic acid; 3-Chloro-5-(ethoxycarbonyl)-2-pyridinecarboxylic acid; CAS 1200497-77-3
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Ethoxycarbonyl)-Pyridine-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.