Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Bromo-2-[[(Cyanomethyl)[(4-Methylphenyl)Sulfonyl]Amino]Methyl]-1-(Phenylsulfonyl)-, Methyl Ester is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring bromo, sulfonyl, and cyano functionalities, makes it a critical intermediate for constructing novel pharmacologically active compounds. This high-purity intermediate is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in kinase inhibitor and oncology research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and cellular signaling pathways.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for the production of complex, proprietary molecules.
• Heterocyclic Compound Library Synthesis: Used to generate diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Bromo-2-[[(Cyanomethyl)[(4-Methylphenyl)Sulfonyl]Amino]Methyl]-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	1200130-74-0
Molecular Formula	C25H21BrN4O6S2
Molecular Weight	617.49 g/mol
Synonyms	5-Bromo-2-[[(cyanomethyl)[(4-methylphenyl)sulfonyl]amino]methyl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 5-bromo-2-((N-(cyanomethyl)-4-methylphenylsulfonamido)methyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo-2-[[(cyanomethyl)[(4-methylphenyl)sulfonyl]amino]methyl]-1-(phenylsulfonyl)-, methyl ester; 1200130-74-0; 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate derivative; Tosyl-cyanoamino methyl pyrrolopyridine ester
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Our quality system includes comprehensive analytical characterization using HPLC, NMR, and LC-MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting critical quality attributes. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.