Description

(2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-6-o-Methyl-Guanosine CAS NO 1199809-27-2 is a high-purity, modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and key intermediate in the synthesis of novel therapeutic agents, particularly in the field of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of antiviral and anticancer nucleotide analogs.
• Antiviral Drug Research: Used in the R&D of novel therapeutics targeting RNA viruses, leveraging its modified sugar moiety to enhance metabolic stability and binding affinity.
• Oncology Research: Investigated as a component in prodrugs and targeted cancer therapies that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Tool: Employed in enzymatic and metabolic studies to understand the incorporation and effects of modified nucleotides.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Process Chemistry & Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for process development and cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-6-o-Methyl-Guanosine
CAS No.	1199809-27-2
Molecular Formula	C12H16FN5O4
Molecular Weight	313.29 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2'-C-methylguanosine; 2'-Fluoro-2'-C-methylguanosine; 6-O-Methyl-2'-deoxy-2'-fluoro-2'-C-methylguanosine; (2R)-2'-Deoxy-2'-fluoro-2'-methyl-6-O-methylguanosine; 2'-F-2'-C-Me-Guanosine; 2'-Fluoro-2'-methylguanosine derivative; Guanosine, 2'-deoxy-2'-fluoro-2'-C-methyl-, 6-methyl ether; (2'R)-2'-Deoxy-2'-fluoro-2'-C-methyl-6-O-methylguanosine
EINECS	Contact for details

Quality Control

Our (2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-6-o-Methyl-Guanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities to meet the exacting standards of pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.