Description

Cerdulatinib CAS NO 1198300-79-6 is a potent and selective small molecule inhibitor targeting Janus kinases (JAK) and Spleen tyrosine kinase (SYK). This dual-action mechanism makes it a critical compound for advanced research in oncology and immunology, particularly for investigating signaling pathways in hematologic malignancies and autoimmune disorders. It is an essential research chemical for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on developing novel targeted therapies.

Application

• Pharmaceutical Research & Development: Primary use as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical-stage drug discovery programs.
• Oncology Studies: Investigation of its efficacy in models of B-cell and T-cell lymphomas, leukemias, and other cancers driven by JAK/SYK signaling pathways.
• Immunology & Autoimmune Disease Research: Exploration of therapeutic potential for conditions like rheumatoid arthritis, lupus, and psoriasis where JAK/SYK inhibition is relevant.
• Biochemical Assay Development: Utilized as a key tool compound in high-throughput screening (HTS) and mechanism-of-action studies to understand kinase inhibition profiles.
• Academic Research: Serves as a vital reagent in university and institutional labs for fundamental research into cellular signaling and immune response modulation.

Basic Information

Product Name	Cerdulatinib
CAS No.	1198300-79-6
Molecular Formula	C₂₃H₂₃N₇O
Molecular Weight	413.48 g/mol
Synonyms	PRT062070; PRT 2070; PRT-2070; 8-Fluoro-3-((2-(pyrrolidin-1-yl)pyrimidin-5-yl)methyl)-1,3,4,10-tetrahydro-2H-[1,4]oxazino[4,3-a]indol-2-one; (R)-8-Fluoro-3-((2-(pyrrolidin-1-yl)pyrimidin-5-yl)methyl)-1,3,4,10-tetrahydro-2H-[1,4]oxazino[4,3-a]indol-2-one
EINECS	Contact for details

Quality Control

Our Cerdulatinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and comprehensive residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.