Description

1-(6-(Difluoromethoxy)Pyridin-3-Yl)Ethanone is a high-value pyridine derivative and a key fluorinated building block in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoromethoxy-substituted pyridine core imparts desirable metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or organic semiconductors, where fluorination tunes electronic properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-(6-(Difluoromethoxy)Pyridin-3-Yl)Ethanone
CAS No.	1198166-10-7
Molecular Formula	C8H7F2NO2
Molecular Weight	187.15 g/mol
Synonyms	1-[6-(Difluoromethoxy)pyridin-3-yl]ethanone; 1-[6-(Difluoromethoxy)-3-pyridinyl]ethan-1-one; 6-(Difluoromethoxy)pyridin-3-yl methyl ketone; 3-Acetyl-6-(difluoromethoxy)pyridine; 5-Acetyl-2-(difluoromethoxy)pyridine; DFMP-Acetone; CAS 1198166-10-7
EINECS	Contact for details

Quality Control

Every batch of 1-(6-(Difluoromethoxy)Pyridin-3-Yl)Ethanone is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.