Description

Methyl 3-Iodo-1-Tosyl-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel pharmaceuticals and agrochemicals, particularly those targeting kinase inhibition. Its unique structure, featuring a halogenated pyrrolopyridine core with a tosyl-protected nitrogen and a methyl ester, offers versatile sites for further functionalization, making it indispensable for medicinal chemistry programs and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Agrochemical Development: Used in the research and synthesis of novel active ingredients for crop protection products.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Organic Synthesis Building Block: Facilitates cross-coupling reactions (e.g., Suzuki, Sonogashira) and other transformations to construct complex heterocyclic systems.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	Methyl 3-Iodo-1-Tosyl-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylate
CAS No.	1198097-28-7
Molecular Formula	C₁₆H₁₃IN₂O₄S
Molecular Weight	456.25 g/mol
Synonyms	Methyl 3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 3-iodo-1-[(4-methylphenyl)sulfonyl]-, methyl ester; 3-Iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; Methyl 3-iodo-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 1-Tosyl-3-iodo-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; CAS 1198097-28-7
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Iodo-1-Tosyl-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced spectroscopic and chromatographic methods (HPLC, NMR, LC-MS).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.