Description

Brigatinib CAS NO 1197953-54-0 is a potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor. This small molecule pharmaceutical intermediate is critical for the development of targeted cancer therapies, offering significant potential in treating non-small cell lung cancer (NSCLC) and other malignancies driven by ALK rearrangements. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and advanced chemical synthesis facilities engaged in oncology drug development.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key intermediate in the commercial production of the targeted oncology drug Brigatinib.
• Oncology Research & Development: Used as a reference standard and building block in preclinical and clinical research for ALK-positive cancers.
• Process Chemistry Development: Serves as a critical compound for optimizing scalable synthetic routes and purification processes in pharmaceutical manufacturing.
• High-Purity Reference Standard: Employed in analytical method development, validation, and quality control testing within regulatory environments.
• Drug Discovery Programs: Utilized in medicinal chemistry for creating novel ALK inhibitor analogs and combination therapies.
• Contract Manufacturing: Supplied to CMOs and CDMOs producing finished dosage forms for global clinical trials and commercial markets.

Basic Information

Product Name	Brigatinib
CAS No.	1197953-54-0
Molecular Formula	C29H39ClN7O2P
Molecular Weight	584.09 g/mol
Synonyms	AP-26113; Briganix; Alunbrig (Brand Name); 5-Chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine; (R)-5-Chloro-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-N4-(2-(dimethylphosphoryl)phenyl)pyrimidine-2,4-diamine
EINECS	Contact for details

Quality Control

Our Brigatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.