Description

5-Bromo-2-(trifluoromethyl)-4-hydroxypyridine is a high-value, multi-functional heterocyclic building block characterized by its bromo and trifluoromethyl substituents. This compound is essential for medicinal chemistry research and the development of advanced agrochemicals, offering a versatile scaffold for structure-activity relationship (SAR) studies. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing substituents.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)-4-hydroxypyridine
CAS No.	1196156-74-7
Molecular Formula	C6H3BrF3NO
Molecular Weight	241.99 g/mol
Synonyms	4-Hydroxy-5-bromo-2-(trifluoromethyl)pyridine; 5-Bromo-4-hydroxy-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-5-bromo-4-pyridinol; 5-Bromo-2-trifluoromethyl-4-hydroxypyridine; 5-Bromo-2-trifluoromethylpyridin-4-ol; 4-Pyridinol, 5-bromo-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)-4-hydroxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.