Description

2-Chloro-6-Trifluoromethyl-Isonicotinic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its molecular architecture, featuring both chloro and trifluoromethyl substituents, provides unique reactivity and physicochemical properties essential for creating sophisticated target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Serves as a critical precursor in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts, enabling challenging chemical transformations.
• Material Science Precursor: Employed in the synthesis of advanced organic materials, such as liquid crystals and electronic chemicals, where its specific halogen and fluorine pattern modifies material properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-6-Trifluoromethyl-Isonicotinic Acid Ethyl Ester
CAS No.	1196154-43-4
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.60 g/mol
Synonyms	Ethyl 2-Chloro-6-(trifluoromethyl)isonicotinate; 2-Chloro-6-(trifluoromethyl)pyridine-4-carboxylic Acid Ethyl Ester; 4-Pyridinecarboxylic acid, 2-chloro-6-(trifluoromethyl)-, ethyl ester; 2-Chloro-6-trifluoromethyl-isonicotinic acid ethyl ester; Ethyl 2-chloro-6-trifluoromethylisonicotinate; 2-Chloro-6-trifluoromethylpyridine-4-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Trifluoromethyl-Isonicotinic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.