Description

Ethyl 2-Methyl-4-(Trifluoromethyl)Nicotinate is a high-value fluorinated nicotinate derivative, a key building block in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which is strategically incorporated into target molecules to enhance their metabolic stability, lipophilicity, and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group improves efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry for constructing complex ligands that modulate catalytic activity in asymmetric synthesis.
• Fluorine Chemistry Library Building: A fundamental scaffold for constructing diverse compound libraries in medicinal chemistry for high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Ethyl 2-Methyl-4-(Trifluoromethyl)Nicotinate
CAS No.	1196153-66-8
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	Ethyl 2-Methyl-4-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-methyl-4-(trifluoromethyl)-, ethyl ester; 4-(Trifluoromethyl)-2-methylnicotinic acid ethyl ester; Ethyl 4-(trifluoromethyl)-2-methylnicotinate; 2-Methyl-4-trifluoromethyl-nicotinic acid ethyl ester; Ethyl 2-methyl-4-(trifluoromethyl)nicotinate; Nicotinic acid, 2-methyl-4-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Methyl-4-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.