Description

6-Chloro-4-(Trifluoromethyl)Pyridin-2-Ol is a high-value, multi-functional pyridine derivative, distinguished by its trifluoromethyl and chloro substituents which confer unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, enabling the development of novel active ingredients. It is essential for research and production in the agrochemical and pharmaceutical sectors, where its structural motifs are leveraged to enhance the bioactivity and metabolic stability of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and manufacturing of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science Precursor: Acts as a building block for creating specialized ligands, catalysts, and functionalized polymers used in advanced material applications.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring novel heterocyclic chemistry, fluorination reactions, and structure-activity relationship (SAR) studies.
• Liquid Crystal & Electronic Chemicals: Serves as a starting material for synthesizing fluorinated compounds used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).

Basic Information

Product Name	6-Chloro-4-(Trifluoromethyl)Pyridin-2-Ol
CAS No.	1196153-11-3
Molecular Formula	C6H3ClF3NO
Molecular Weight	197.54 g/mol
Synonyms	2-Hydroxy-6-chloro-4-(trifluoromethyl)pyridine; 6-Chloro-4-(trifluoromethyl)-2-pyridinol; 6-Chloro-4-(trifluoromethyl)-2(1H)-pyridinone; 4-(Trifluoromethyl)-6-chloropyridin-2-ol; 2-Pyridinol, 6-chloro-4-(trifluoromethyl)-; 6-Chloro-4-trifluoromethylpyridin-2-ol
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(Trifluoromethyl)Pyridin-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.